Gordon Research Conferences
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Conference Program
 
Membrane Transport Proteins
August 15-20, 2010
University of New England
Biddeford, ME
Chair:
Ulrik Gether

Vice Chair:
Robert Edwards

The Gordon Research Conference (GRC) on Membrane Transport Proteins will be held for the 7th time and continue to bring together researchers from many different areas in the field of membrane transport. It is a major goal of the conference to bring together people who do not normally interact and to ensure participation of as many students, post docs and young investigators as possible. To reinforce the international aspect of the conference has alternated between European and US venues. This time the conference returns to University of New England, which is situated on the beautiful coast of southern Maine. The conference sessions will cover a spectrum of different membrane transport proteins including ion pumps, ABC transporters, ion coupled transporters, neurotransmitter transporters, vesicular transporters and ion channels. The talks will describe the most recent developments in our understanding of membrane transport protein structure and mechanisms as well as the newest insights into the role of genetic variation in transporters for disease development, the pharmacology and physiology of transport proteins, the use of computational biology and high through put approaches in transporter research, the cellular mechanisms regulating transporter activity and the physiological and pathophysiological function of transporters in the brain.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:35 pmWelcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pmTransporter conformational dynamics
Discussion Leader: Peter Henderson (University of Leeds, UK)
7:35 pm - 8:00 pm Baruch Kanner (Hebrew University Hadassah Medical School, Jerusalem)
"Two families of neurotransmitter transporters - different strategies to achieve the same goal"
8:00 pm - 8:05 pm Discussion
8:05 pm - 8:30 pm Hassane Mchaourab (Vanderbilt University)
"Transporter dynamics studied by EPR spectroscopy"
8:30 pm - 8:35 pm Discussion
8:35 pm - 9:00 pm Amy L. Davidson (Purdue University)
"The ABC maltose transporter: Alternating access mediated by rigid-body rotations"
9:00 pm - 9:05 pm Discussion
9:05 pm - 9:25 pm Alexander D. Cameron (Imperial College, UK)
"Structure of Mhp1 in the inward facing conformation"
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTransporter structure and mechanism
Discussion Leaders: Shimon Schuldiner (Hebrew University of Jerusalem) and Poul Nissen (University of Aarhus, Denmark)
9:00 am - 9:25 am Nico Reyes (Cornell University)
"Mechanism of glutamate transporters studied by X-ray crystallography"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Christine Ziegler (Max Planck Institute of Biophysics, Frankfurt am Main)
"Molecular basis of transport and regulation in the Na1/betaine symporter BetP"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 am Poul Nissen (University of Aarhus, Denmark)
"Structure and mechanisms of the calcium and sodium-potassium pumps"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Gary Rudnick (Yale University)
"Ion coupling in the neurotransmitter-sodium symporter family"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Da-Neng Wang (New York University School of Medicine)
"Structural basis of selectivity and gating mechanism of the organic-ion channel, FocA"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Lucy Forrest (Max Planck Institute of Biophysics, Frankfurt am Main)
"Symmetry and the art of transport: inverted-topology repeats reveal alternate conformations of neurotransmitter transporters"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Saba Abdul Hussein (MRC laboratory of molecular biology (lmb), Cambridge)
"Conformational thermostabilisation of the serotonin transporter"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmComputational biology and high through put approaches in transporter research
Discussion Leaders: Harel Weinstein (Cornell University) and Jonathan Javitch (Columbia University)
7:30 pm - 7:55 pm Emad Tajkhorshid (University of Illinois at Urbana-Champaign)
"Computational approaches: transporters and channels"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Harel Weinstein (Cornell University)
"Dynamics of Neurotransmitter:Sodium Symporters determines function and changes the membrane environment"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Min Li (Johns Hopkins University)
"Chemical biology of ion channels and transporters"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Oliver Beckstein (University of Oxford, UK)
"Molecular simulations of ion-coupled transporters"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Iris Nasie (Hebrew University of Jerusalem)
"Topologically random insertion of EmrE supports a pathway for evolution of inverted repeats in ion-coupled transporters"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransport proteins: pharmacology, physiology and disease
Discussion Leaders: Robert Tampe (Biocenter, Goethe-University, Frankfurt) and Randy Blakely (Vanderbilt University)
9:00 am - 9:25 am Robert Tampé (Biocenter, Goethe-University, Frankfurt)
"ABC transporters and immunity"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Marianne Wessling-Resnick (Harvard University)
"Iron transporter function and small molecule inhibitors"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 am Rajini Rao (Johns Hopkins University)
"Calcium signaling by the secretory pathway Ca2+-ATPase in mammary tumors"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Leon O. Murphy (Novartis Institutes for BioMedical Research, Cambridge, MA)
"Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy"
11:40 am - 11:50 am Discussion
11:50 am - 12:00 pm Shushi Nagamori (Osaka University, Japan)
"CE-MS based metabolome analysis in knockout mice reveals real physiological substrates of an organic anion transporter"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pm Markus Seeger (University of Zürich, Switzerland)
"In vitro selection of binders against ABC transporters exemplified by LmrCD-specific DARPins"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransporter genetics and disease
Discussion Leader: Manuel Palacin (University of Barcelona)
7:30 pm - 7:55 pm Randy Blakely (Vanderbilt University)
"Change that Matters: Serotonin Transporter Genetic Variation and Autism Traits"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Michael Köttgen (University Hospital Freiburg)
"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Stefan Broer (Australian National University, Canberra)
From simple to complex - the genetics of renal aminoacidurias
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm Michael R. Koelle (Yale University School of Medicine)
"Two types of chloride-extruding transporters are required for GABAA receptor-mediated inhibition in C. elegans"
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Claudia Doberenz (University Halle, Germany)
"Characterisation of the Formate Channel Protein FocA of Escherichia coli"
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular transporters and channels
Discussion Leader: Robert Edwards (UCSF)
9:00 am - 9:25 am Yoshinori Moriyama (Okayama University, Japan)
"Vesicular aspartate and nucleotide transporters"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Thomas J. Jentsch (Lebiniz-Institut für Molekulare Pharmakologie and Max-Delbrück-Centrum für Molekulare Medizin, Berlin)
"CLC Cl-/H+ exchangers in endosomes and lysosomes"
10:00 am - 10:10 am Discussion
10:10 am - 10:40 am Coffee Break
10:40 am - 11:05 am Joe Mindell (National Institute of Neurological Disorders and Stroke)
"The Cl-/H+ antiporter ClC-7 in lysosomes"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Shigeo Takamori (Doshisha University, Kyoto, Japan)
"A chloride conductance in the vesicular glutamate transporters"
11:40 am - 11:50 am Discussion
11:50 am - 12:00 pm Pascal Courville (Stanford University)
"The role of titratable residues in the function of sialin"
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pm Thomas Hnasko (UCSF)
"Vesicular glutamate transport promotes monoamine storage through a mechanism distinct from chloride"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTransporters and brain function in health and disease
Discussion Leader: Aurelio Galli (Vanderbilt University)
7:30 pm - 7:55 pm Kai Kaila (University of Helsinki)
"Cation-chloride cotransporters and neuronal function"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pm Jeff Rothstein (Johns Hopkins University)
"Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pm Harald Sitte (Medical University of Vienna)
"ER export, assembly and lipid regulation of monoamine transporters"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pm Lynette Daws (University of Texas Health Science Center at San Antonio)
"Unfaithful neurotransmitter transporters: focus on serotonin uptake and implications for antidepressant efficacy"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
9:00 am - 12:30 pmCellular regulation of transporters
Discussion Leader: Lydia Aguilar-Bryan (Pacific Northwest Research Institute)
9:00 am - 9:25 am Jonathan Javitch (Columbia University)
"Delineating molecular mechanisms of amphetamine action in Drosophila melanogaster"
9:25 am - 9:30 am Discussion
9:30 am - 9:55 am Haoxing Xu (University of Michigan)
"Regulation of the type IV mucolipidosis-associated protein TRPML1 - an endolysosomal iron release channel"
9:55 am - 10:00 am Discussion
10:00 am - 10:30 am Coffee Break
10:30 am - 10:55 am Amira Klip (Hospital for Sick Children, Toronto)
"Exocytic and endocytic regulation of GLUT4 traffic"
10:55 am - 11:00 am Discussion
11:00 am - 11:25 am Bernard C. Rossier (University of Lausanne)
"Activation of the epithelial sodium channel (ENaC) by serine proteases"
11:25 am - 11:30 am Discussion
11:30 am - 11:55 am Gonzalo E. Torres (University of Pittsburgh)
"Monoamine transporter protein-protein interactions"
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm Haley Melikian (University of Massachusetts Medical School)
"PKC-mediated dopamine transporter internalization requires the plasma membrane GTPase, Rin"
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Jan H. Reiling (Whitehead Institute for Biomedical Research)
"The putative transporter MFSD2A mediates tunicamycin-induced ER stress"
12:25 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote presentation
Discussion Leader: Ulrik Gether (University of Copenhagen)
7:30 pm - 8:30 pm David Clapham (Harvard University)
"Mitochondrial calcium entry mechanisms"
8:30 pm - 9:00 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Last Updated: August 6, 2010
 
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